clinical effectiveness

In fact, everything looks a little different. Psevdonukleozid Cheap Generic Viagra differs from the natural just one more group. Host cell does not recognize the anomaly and artificial nucleosides, easily penetrate into any of the Purchase Levitra Sale Online host cells and infected ineinfitsirovannyh. Of course, that the metabolic transformation of artificial nucleosides, as well as their influence on the processes of biosynthesis, are virtually identical, and in Brand Name Viagra Prescription those willows other cells. In other words, psevdonukleozidy not as selective as we would like, but it significantly narrows the choice of effective, but non-toxic drugs.

The first such medication was acyclovir (Zovirax) - analog of Cheap Brand Name Cialis the natural nucleoside thymidine called. The main advantage of the drug lies in the fact that the non-contaminated Generic Levitra Pills human cells can not effectively phosphorylate aciclovir, and therefore, acyclovir monophosphate is formed predominantly in infected cells, which have at their Cialis Drugs Online Pharmacy disposal the necessary viral enzyme. Under the action of cellular enzymes acyclovir monophosphate into a triphosphate (Fig. 3), which is directly "makes" adjustments in the synthesis of "subsidiary" of Order Viagra Tablets Online viral DNA. First, it inhibits viral DNA polymerase (though acting with and on the cellular DNA polymerase, but much weaker). And, secondly, being included in the growing chain of viral DNA, he thereby stops its growth.


Such a mechanism of action provides a pronounced Tadalafil Sildenafil Vardenafil clinical effect in 75-95% of patients with various herpes virus infections.

"Descendant" acyclovir, valacyclovir, is a valine ester of Acyclovir. Posravneniyu with its predecessor, it has several advantages. Bioavailability Valacyclovir is 70-80% (compared Buy Generic Cialis Online with acyclovir does not exceed 30%), which significantly reduces the number of intakes (s5do 1-2 times a day). And this, moreover, that the clinical effectiveness in the treatment of acute and chronic herpesviral infections it is 25-40% greater than acyclovir. However, in some respects inferior vatsiklovir acyclovir. Acyclovir and still remains the only drug for intravenous administration, non-haemo-, hepato-and nephrotoxic Order Brand Levitra Discount properties and not giving immunosuppressive and teratogenic effects.